How a popular antidepressant drug could rewire the brain

(American Chemical Society) Prozac®, the trade name for the drug fluoxetine, was introduced to the US market for the treatment of depression in 1988. Thirty years later, scientists still don't know exactly how the medication exerts its mood-lifting effects. Now, researchers report that, in addition to the drug's known action on serotonin receptors, fluoxetine could rearrange nerve fibers in the hippocampus of mouse brains. They report their results in ACS Chemical Neuroscience.